Cover Feature: A Cytotoxic Bis(1,2,3‐triazol‐5‐ylidene)carbazolide Gold(III) Complex Targets DNA by Partial Intercalation (Chem. Eur. J. 32/2021)

Strong DNA deformation required for extremely slow DNA threading intercalation by a binuclear ruthenium complex

DNA intercalation by threading is expected to yield high affinity and slow dissociation, properties desirable for DNA-targeted therapeutics. To measure these properties, we utilize single molecule DNA stretching to quantify both the binding affinity and the force-dependent threading intercalation kinetics of the binuclear ruthenium complex Δ,Δ-[μ-bidppz-(phen)4Ru2]4+ (Δ,Δ-P). We measure the DNA...

DNA intercalation without flipping in the specific ThaI–DNA complex

The PD-(D/E)XK type II restriction endonuclease ThaI cuts the target sequence CG/CG with blunt ends. Here, we report the 1.3 Å resolution structure of the enzyme in complex with substrate DNA and a sodium or calcium ion taking the place of a catalytic magnesium ion. The structure identifies Glu54, Asp82 and Lys93 as the active site residues. This agrees with earlier bioinformatic predictions an...

Chemistry under cover: tuning metal-graphene interaction by reactive intercalation.

Intercalation of metal atoms is an established route for tuning the coupling of graphene to a substrate. The extension to reactive species such as oxygen would set the stage for a wide spectrum of interfacial chemistry. Here we demonstrate the controlled modification of a macroscopic graphene-metal interface by oxygen intercalation. The selective oxidation of a ruthenium surface beneath graphen...

Microsoft Word - Wang J Biol Chem Revised

From Key Laboratory of Photosynthesis and Molecular Environment Physiology, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China , Institute of Molecular Cell Biology, Hebei Normal University, Shijiazhuang, Hebei Province, 050016, China, and Department of Plant Biology, College of Biological Sciences,...

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